Symbol
Name
ID

Glra1
glycine receptor, alpha 1 subunit
MGI:95747

Phenotype annotations related to nervous system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Frequent falls	Exaggerated startle response	Myoclonus	Hypokinesia	Seizure	Nocturnal seizures
Disease(s) Associated with GLRA1
hyperekplexia 1

Mouse Phenotypes

nervous system phenotype

increased susceptibility to pharmacologically induced seizures

seizures

tonic-clonic seizures

decreased neuron number

abnormal nervous system electrophysiology

abnormal single cell response

abnormal CNS synaptic transmission

abnormal inhibitory postsynaptic currents

abnormal miniature inhibitory postsynaptic currents

decreased miniature inhibitory postsynaptic current amplitude

decreased miniature inhibitory postsynaptic current frequency

abnormal channel response

Availability

Mouse Genotype

Glra1^m1Cpai/Glra1^m1Cpai

Glra1^nmf11/Glra1^nmf11

Glra1^spd-ot9J/Glra1^spd-ot9J

Glra1^spd-ot/Glra1^spd-ot

Glra1^tm1.1Geh/Glra1^tm1.1Geh

Glra1^tm1Betz/Glra1^tm1Betz

Glra1^tm1Rah/Glra1^tm1Rah

Glra1^tm2.1Geh/Glra1^tm2.1Geh

Glra1^tm1Rah/Glra1⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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